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Warfarin's fewer powerful R-enantiomer is metabolized partially by CYP3A4 (and also CYP1A2 and CYP2C19). Observe INR much more usually if coadministered with inhibitors of such isoenzymes and adjust warfarin dose if wanted.Coadministration of encorafenib with sensitive CYP3A4 substrates may possibly cause elevated toxicity or lowered efficacy of th